tag:blogger.com,1999:blog-224851152012-02-17T06:41:09.149+05:30Bioinformatics derives knowledge from computer analysis of biological data. These can consist of the information stored in the genetic code, but also experimental results from various sources, patient statistics, and scientific literature.Bioinformatics is a rapidly developing branch of biology and is highly interdisciplinary, using techniques and concepts from informatics, statistics, mathematics, chemistry, biochemistry, physics, and linguistics.Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.comBlogger501100tag:blogger.com,1999:blog-22485115.post-87498714654834945342008-06-17T12:27:00.002+05:302008-06-17T12:32:25.907+05:30

Bioinfinite blog is BACK!! Forthcoming posts will put forth the developments in the field of Bioinformatics and its associated fields!

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-3019104618686934392007-10-18T18:25:00.000+05:302007-10-18T18:46:12.105+05:30

Source: sanger.ac.ukGenes and disease? It's what you do with what you haveA new study published in Nature Genetics on Sunday 16 September 2007 show that common, complex diseases are more likely to be due to genetic variation in regions that control activity of genes, rather than in the regions that specify the protein code.This surprising result comes from a study at the Wellcome Trust Sanger

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-48548672375491473452007-09-20T11:47:00.000+05:302007-09-20T11:50:57.021+05:30

An extract from eyeondna.comAccording to myDanwei, “a a pioneer of developing the next generation organization, people, salary, and job information searching and data mining platforms,” here are some current genetics salaries in biotechnology companies:Microarray Software Engineer - $88,400Statistical Genetics Analyst - $85,000Senior Scientist - $95,000Bioinformatics Research Associate -

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-32598504778836004492007-09-08T13:56:00.000+05:302007-09-08T13:57:45.874+05:30

When people refer to the field of bioinformatics, they’re usually referring to two overlapping areas. The first is what you would call “bioinformatics”, which is more technical, and examples are creating tools to analyse data for biologists, or specific databases to store and retrieve information. For example if you created a new tool that could analyse microarray data in a way that hasn’t been

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-85804693203191200122007-07-07T18:55:00.000+05:302007-07-07T19:06:38.948+05:30

Check for the updates in here soon.. For mean time, why can't u post me some useful info 2 bioinfinite@hotmail.com.. so that i could publish that in the blog... Catch up with the LATEST of BIOINFO and move up with thr trend..

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-88378467348459925912007-04-30T12:45:00.000+05:302007-04-30T12:54:33.806+05:30

alanine - ala - A arginine - arg - R asparagine - asn - N aspartic acid - asp - D cysteine - cys - C glutamine - gln - Q glutamic acid - glu - E glycine - gly - G histidine - his - H isoleucine - ile - I leucine - leu - L lysine - lys - K methionine - met - M phenylalanine - phe - F proline - pro - P serine - ser - S threonine - thr - T tryptophan - trp - W tyrosine - tyr - Y valine - val - V

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-91579942784261504522007-04-26T15:52:00.000+05:302007-04-26T16:00:41.028+05:30

source: cnet news Red Hat is taking a second crack at trying to spread its open-source philosophy beyond the realm of software development. On Wednesday, the Raleigh, N.C.-based Linux seller announced a partnership with the nearby University of North Carolina to try to encourage use of the open, collaborative model in the fields of health care research, biotechnology, bioinformatics and

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com1tag:blogger.com,1999:blog-22485115.post-50385931371783743952007-04-21T11:14:00.000+05:302007-04-21T11:19:18.782+05:30

Stainless steel door handles and taps at a hospital are being replaced with copper ones in an effort to reduce the presence of superbugs Staphylococcus aureus MRSA and Clostridium difficile.Birmingham's Selly Oak Hospital is swapping steel for copper in an 18-month trial to test the findings. 80% of hospital MRSA transmission is believed to come from contact with surfaces such as door handles,

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com1tag:blogger.com,1999:blog-22485115.post-37511268427278882162007-04-18T11:44:00.000+05:302007-04-18T12:14:02.181+05:30

hi blog readers,i've jus made up a summary of all bioinformatics schools in UG/PG category.. May b i'll start posting n a couple of days.. Plz await for them.. If u've any queries, jus comment i'll respond 2 u..U can also review some universities, colleges, certificate programs n send it 2 bioinfinite@hotmail.com... Any contributions u wanna do to bioinfinite (may be some articles, descriptors of

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-31557081532709702472007-04-17T15:15:00.000+05:302007-04-17T15:26:19.410+05:30

Phenomics describes the state of an organism as it changes with time. It is a word he coined at a guest lecture he gave at the University of Waterloo in 1996 by Steven A. Garan, Director of the Aging Research Centre (ARC). Then what s meant by phenome?? Answer is right down.. A phenome is the set of all phenotypes expressed by a cell, tissue, organ, organism, or species. A phenome includes

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-7691218588719227512007-04-16T15:55:00.000+05:302007-04-16T16:05:16.485+05:30

SMD stores raw and normalized data from microarray experiments, as well as their corresponding image files. SMD provides interfaces for data retrieval, analysis and visualization.SMD stores raw and normalized data from microarray experiments, as well as their corresponding image files. In addition, SMD provides interfaces for data retrieval, analysis and visualization.Link: http://genome-www5.

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-39544837861270419422007-04-12T15:08:00.000+05:302007-04-12T15:10:23.745+05:30

"Junk" DNA is a collective label for the portions of the DNA sequence of a chromosome or a genome for which no function has yet been identified. About 97% of the human genome has been designated as "junk", including most sequences within introns and most intergenic DNA. While much of this sequence may be an evolutionary artifact that serves no present-day purpose, some is believed to function in

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-61263218726397546022007-04-07T12:30:00.000+05:302007-04-07T12:33:32.752+05:30

NCBI is holding a beta test for a new BLAST interface design. One major improvement is a new "Recent Results" feature that provideslinks to all of your recent BLAST search results.Another is "SavedStrategies", which allows you to save BLAST forms with their parameters and use them later. Saved Strategies requires a free MyNCBI account, andis compatible with existing accounts. Signing in to MyNCBI

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-32875228640830488322007-04-07T12:12:00.000+05:302007-04-07T12:21:23.821+05:30

To my reviewer's request, i've posted this, Folding @ Home is an initiative started by Stanford University to have a distributed computing environment, where each online user can contibute a share of his/her computer process to the folding program( we've to download the program and install it to be a part of the Project). Folding@Home uses novel computational methods coupled to distributed

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-68440088257683335122007-04-06T14:56:00.000+05:302007-04-06T15:07:47.873+05:30

source: Science Daily A mathematician at the University of York has been awarded a Research Leadership Award of more than £700,000 by the Leverhulme Trust to study the geometry of viruses. Viruses have highly symmetrical external shells formed from proteins that encapsulate the viral genome. Dr Twarock has developed a method for encoding the structures of these protein shells that pinpoint the

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-5928430102155221972007-04-04T11:32:00.000+05:302007-04-04T11:35:06.107+05:30

Decoys ‘R’Us database contains a wide variety of decoys generated by different methods with the aim of fooling scoring functions. Decoys are computergenerated conformations of protein sequences that possess some characteristics of native proteins, but are not biologically real.Decoys have been based on discrete-state models, molecular dynamics trajectories, crystal structures of different

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-65565664733973737582007-04-04T10:38:00.000+05:302007-04-04T10:40:14.701+05:30

Human Protein Reference Database (HPRD) that integrates information relevant to the function of human proteins in health and disease.Data pertaining to thousands of protein-protein interactions, posttranslational modifications, enzyme/substrate relationships, disease associations, tissue expression, and subcellular localization for each protein in the human proteome. Go to Human Protein

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-83923930287455065342007-03-29T09:43:00.000+05:302007-03-29T10:40:12.974+05:30

STRING is a database of known and predicted protein-protein interactions.The interactions include direct (physical) and indirect (functional) associations; they are derived from four sources: Genomic ContextHigh-throughput Experiments(Conserved) CoexpressionPrevious Knowledge STRING quantitatively integrates interaction data from these sources for a large number of organisms, and transfers

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-62000173820676842222007-03-28T10:12:00.000+05:302007-03-28T10:14:06.515+05:30

RNA interference, or RNAi, is a way for cells to regulate which genes would be expressed. This amazing phenomenon was first observed in petunias, when a scientist called Rich Jorgensen introduced a pigment-producing gene under the control of a powerful promoter. Instead of the expected deep purple color in the petunia, the result was a mixture of variegated and white petunias.RNAi was named the

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-56985188882054478922007-03-26T10:20:00.000+05:302007-03-26T10:21:58.925+05:30

A network of Playstation computers might help Danish scientists to solve themystery of prostate cancer.A team of scientists has enlisted the help of Playstation 3 owners to help themcrack the code for prostate cancer.Brian Vest, a professor in computer science at the University of Copenhagen,realised that the lightning fast processor in Playstation 3 can double as ahome computer. Together with

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com1tag:blogger.com,1999:blog-22485115.post-4992538619161386912007-03-23T10:00:00.000+05:302007-03-23T10:13:55.667+05:30

Biophysics (also biological physics) is an interdisciplinary science that applies the theories and methods of physics, to questions of biology. Biophysics research today comprises a number of specific biological studies, which do not share a unique identifying factor, nor subject themselves to clear and concise definitions. The studies included under the umbrella of biophysics range from sequence

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-9996752319764283332007-03-20T11:20:00.000+05:302007-03-20T11:22:19.160+05:30

Hi 2 all,I recently browsed through the available books, magazines for bioinformatics for the convenience of my blog readers . I hand picked some books that all bioinformaticists must need that u may not aware of.. So u can find the books that i've picked in the following page..BIOINFLUX STORE

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-10298779619467560992007-03-20T11:06:00.000+05:302007-03-20T11:12:27.380+05:30

source: ScienceDaily A U.S.-led international group of scientists has expanded a lingua franca used to describe the activities of genes in living organisms.The expansion is part of the unified language called Gene Ontology, which provides terms that scientists can use to describe the complex events that occur when a pathogenic or beneficial microbe encounters its host.The initiative is part of

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-73581124291751683822007-03-14T19:02:00.000+05:302007-03-14T19:04:29.905+05:30

For most proteins, there is a particular place inside a cell where they carry out their function. But how do they get there? Scientists from the Charité Berlin, the University of Heidelberg, and the Max Planck Institute for Molecular Genetics in Berlin have now been able to visualize the structure of a "molecular machine" involved in protein sorting using cryo-electron microscopy and single

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-35677055396252313162007-03-14T18:09:00.000+05:302007-03-14T18:13:32.308+05:30

Hi to all my BLOG subscribers,Sorry, i cudn't post blog posts 4 the recent time due 2 server running low on fuel in our research lab.. But anyway, am still striving hard 2 put forward the information watever i get.. Thanks 2 one and all 4 regularly turning 2 my blog...

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-17128627484674317362007-03-07T09:11:00.000+05:302007-03-07T09:20:52.370+05:30

Structure Prediction in 1DLimited computing resources and experimental inaccurices prevent prediction of protein structure from first principles. Therefore, the only succesful structure prediction tools are knowledge-based, using a combination of statistical theory and empirical rules.Secondary Structure Prediction MethodsBasic concept: segments of consecutive residues have preferences for

R.Sitaramhttp://www.blogger.com/profile/17067388907641443771noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-57760392995486549302007-02-26T12:07:00.000+05:302007-02-26T12:13:41.739+05:30

Wikicamp '07 was all about harnessing and understanding the power of Wikis. It was a one day event aimed to bring together the best minds from the Wiki/Internet space to talk about issues, opportunities and what the future and evolution of this valuable tool. It jus got over yesterday that had a huge number of participants registering and the highlight of the camp was the presence of Jimmy Wales,

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-20127749729922833172007-02-16T11:10:00.000+05:302007-02-16T11:29:50.643+05:30

About the Seminar: The Seminar aims at inviting eminent speakers from national and foreign institutes, research laboratories and industries working in the related aspects of protein engineering.Sessions include:Protein and Peptide design Macromolecular RecognitionProtein folding & DynamicsProduction and analysis of recombinant protiensDirected Evolution of Proteins &Protein

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-50389024815047411372007-02-13T10:19:00.000+05:302007-02-10T20:03:59.405+05:30

Reliance Life Sciences, the Mukesh Ambani-controlled biotechnology-driven life sciences company, has received 36 patents from applications filed for 200 rights. The valuation of these patents could not be ascertained. Of the accepted patents, six are design patents, seven product patents and 23 process patents.These patents have been filed in 16 countries, including India and the US. "We are in

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-34225625448948921092007-02-10T19:12:00.000+05:302007-02-10T19:12:21.201+05:30

Hello to all my blog readers,I got this very good informative links of career sites of Bioinformatics, Pharmaceutical companies on searching through the web. I thought this could be useful for everyone... Add this to your favourites for late references...STRAND GENOMICShttp://www.strandgenomics.com/Careershttp://www.strandgenomics.com/careers.htmlMETAHELIX LIFE SCIENCEShttp://www.meta-helix.com/

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-54504954409046836972007-02-06T10:55:00.000+05:302007-02-06T10:57:20.525+05:30

Bio-Suite is an end-to-end software tool for BioInformatics developed at the Life Sciences division of Advanced Technology Center of Tata Consultancy Services Ltd. Bio-Suite is developed in collaboration with Council of Scientific and Industrial Research (CSIR) and several leading Indian academic institutes under the Government of India funded New Millennium Indian Technology Leadership

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-65045814458756114072007-02-06T10:24:00.000+05:302007-02-06T10:27:43.668+05:30

In the 2007 Database Issue of Nucleic Acids Research (A series dedicated to databases in the field of molecular biology) , Alex Batemen has wriiten about the qualities of a good biological database. He pointed the data and web interference condiderations which make a good database. According to him, The quality, quantity and originality of data as well as the quality of the web interface are the

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-12009779450944298302007-01-31T10:09:00.000+05:302007-01-31T10:22:04.112+05:30

The RCSB PDB website now offers improved access to ligand, Single Nucleotide Polymorphism (SNP), and Pfam information. Improved Access to Ligand DataThe PDB chemical components dictionary (formally the HET dictionary) has been remediated to better describe the components that interact with macromolecular structures. This new dictionary has been incorporated with the RCSB PDB database. Options

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-60445761279726118252007-01-20T09:54:00.000+05:302007-01-20T10:03:35.331+05:30

To all my Blog Readers, I've found this site very useful for those who wants to settle up their job in this stream. Am providing the link to the site... Have a look on to it...Site Address: http://biotech.fyicenter.com/interview/Bioinformatics_Interview_Questions_and_Answers.html

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-1168497307097896692007-01-11T12:01:00.000+05:302007-01-11T12:05:07.313+05:30

January 10, 2007 - This work provides important basic information on the flexibility of proteins and their ability to link with other molecules, an area of study which opens enormous possibilities for the design of new drugs.Scientists from the Institute for Research in Biomedicine (IRB Barcelona), the Life Sciences Programme at the Barcelona Supercomputing Center (BSC) and the National

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-1167381008626787072006-12-29T13:50:00.000+05:302006-12-29T14:00:08.903+05:30

The Top Bioinformatics Challenges according to Chris Burge at MIT and his colleagues are as follows...Precise, predictive model of transcription initiation and termination: ability to predict where and when transcription will occur in a genomePrecise, predictive model of RNA splicing/alternative splicing: ability to predict the splicing pattern of any primary transcriptPrecise, quantitative

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-1161599485333951812006-10-23T15:53:00.000+05:302006-11-09T12:14:41.706+05:30

Structure and function can be transferred between similar sequences because they have been conserved over long periods of time. Above 40% sequence identity, homologous proteins tend to have the same function. Function: Biochemical: the chemical interactions ocurring in a protein; Biological: the role within the cell of the protein; Phenotypic: the role played by the protein in the organism as a

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com2tag:blogger.com,1999:blog-22485115.post-1161598403401210382006-10-23T15:29:00.000+05:302006-10-23T15:43:23.640+05:30

Target identification: usually through biological or genetic investigation. An assay to look for modulators (either inhibitors, antagonists, or agonists) of the target activity. High-throughput screen (HTS). Elaboration of the initial small molecule hit through medicinal chemistry: combinatorial chemistry, quantitative structure activity relationships (QSAR), computer-aided drug design (CADD) and

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-1160384688830213272006-10-09T14:22:00.000+05:302006-10-23T15:27:53.016+05:30

Author: James Marriot In the current scenario, bioinformatics market size stands at approximately $840 million. It's poised for a rapid growth with increase of around $1.82 billion by 2007. The Compound Annual Growth Rate - CAGR of the Bioinformatics Market is likely to be around 15 % up till 2010.In the last few years, bioinformatics has achieved acceptance among other markets particularly

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-1159355802531102542006-09-27T16:42:00.000+05:302006-09-27T16:46:42.663+05:30

Thiruvananthapuram, Sep 21:Stressing that the convergence of Bioscience and Information Technology into Bioinformatics has given thrust to genomics-based drug discovery and development, President A P J Abdul Kalam said there was a growing need for new informatics tools to help manage the influx of data from genomics and turn that data into tomorrow's drugs.''Bioinformatics data plays a vital role

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-1157707506235792382006-09-08T14:46:00.000+05:302006-09-08T14:55:06.943+05:30

In their quest to study life, biologists apply engineering knowledge somewhat differently: They "reverse engineer" life forms, test fly them in the computer, and see if they work in silico the way they do in vivo. This technique previously had been employed for small pieces of living cells, such as proteins, but not for an entire life form until now. The accomplishment, performed by computational

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com1tag:blogger.com,1999:blog-22485115.post-1157177969483436432006-09-02T11:46:00.000+05:302006-09-02T11:49:34.906+05:30

Effective October 15, 2006, PDB depositions will be restricted to atomic coordinates that are substantially determined by experimental measurements on specimens containing biological macromolecules. This policy was recommended and endorsed by a working group comprised of structural and computational biologists and endorsed by the wwPDB advisory committee. Thus, theoretical model depositions (such

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-1146243800019439352006-04-28T22:32:00.000+05:302006-04-28T22:33:32.303+05:30

Systems biology is the study of an organism, viewed as an integrated and interacting network of genes, proteins and biochemical reactions which give rise to life. Instead of analyzing individual components or aspects of the organism, such as sugar metabolism or a cell nucleus, systems biologists focus on all the components and the interactions among them, all as part of one system. These

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-1145012928014408582006-04-14T16:17:00.000+05:302006-04-22T17:42:19.810+05:30

People have been talking about personalized medicine, to a point that it almost gets old. Some are firm believers in this revolution and are actively devoting effort to advance it, others wonder whether this is yet another hype, and yet many others may have an impression that, as promising a future as it paints, it may only become reality in another lifetime.Personalized medicine addresses

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com1tag:blogger.com,1999:blog-22485115.post-1144408827356751562006-04-07T16:34:00.000+05:302006-04-21T18:25:05.503+05:30

Scientists have developed a new type of protein array for studying interactions between proteins and other molecules on an extremely small scale. Size is what sets these arrays apart—they are built on a nano-scale (one nanometer equals one-billionth of a meter). The arrays are coated surfaces containing proteins that can be exposed to other proteins and structures in order to study their

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-1142147293818650202006-03-12T11:59:00.000+05:302006-04-21T18:03:35.493+05:30

Surprisingly, the frozen structures from ultra-high-resolution protein crystallography reveal a prevalent, but subtle, mode of local backbone motion coupled to much larger, two-state changes of sidechain conformation. This “backrub” motion provides an influential and common type of local plasticity in protein backbone. Concerted reorientation of two adjacent peptides swings the central sidechain

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-1140936408507911032006-02-26T12:05:00.000+05:302006-04-21T17:58:12.973+05:30

Overview:Fold recognition (FR) is the name give to the process of assigning a known structure (a template) to a sequence of unknown structure (the query). The methodologies used includeStraight sequence methods (like BLAST and PSI-BLAST)Sequence methods incorporating structure, including:- predicted and known secondary structure- structural environments- structural alignments"True" threading

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-1140932286469323672006-02-26T10:41:00.000+05:302006-02-26T11:08:06.703+05:30

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com0tag:blogger.com,1999:blog-22485115.post-1140260302808368032006-02-18T16:23:00.000+05:302006-03-28T22:29:22.853+05:30

Comparative protein modelling uses previously solved structures as starting points, or templates. This is effective because it appears that although the number of actual proteins is vast, there is a limited set of tertiary structural motifs to which most proteins belong. It has been suggested that there are only around 2000 distinct protein folds in nature, though there are many millions of

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com1tag:blogger.com,1999:blog-22485115.post-1139988217990611262006-02-15T12:45:00.000+05:302006-02-15T12:53:38.000+05:30

Hello all bioinfo students around the world!This blog will be useful containing tons of information, links etc.,Make use of it.. Contribute information to the world around you!

Pravinhttp://www.blogger.com/profile/18278176402507656309noreply@blogger.com2