New Web Site Features For Viewing Ligand, SNP, and Pfam Data- PDB

The RCSB PDB website now offers improved access to ligand, Single Nucleotide Polymorphism (SNP), and Pfam information.

Improved Access to Ligand Data

The PDB chemical components dictionary (formally the HET dictionary) has been remediated to better describe the components that interact with macromolecular structures. This new dictionary has been incorporated with the RCSB PDB database. Options available after a search now includes a tab called 'Ligand Hits'. This page lists the ligands known to interact with the structures that match the query.

For example, a search for 'protein kinase' returns 2051 structures and 678 ligands. From the 'Ligand Hits' page, users can find all of the structures that contain that ligand or access information from the 'Ligand Summary' page. This page offers summary information, downloads (definitions and coordinates), and interactive and static views.

Ligand Explorer Tool for Viewing Protein-Ligand Interactions.....

Access to Single Nucleotide Polymorphism (SNP), Pfam, and more .....

Bioinformatics Interview Questions and Answers

To all my Blog Readers,

I've found this site very useful for those who wants to settle up their job in this stream. Am providing the link to the site... Have a look on to it...

Site Address: http://biotech.fyicenter.com/interview/Bioinformatics_Interview_Questions_and_Answers.html

Spanish scientists reveal dynamic map of proteins

January 10, 2007 - This work provides important basic information on the flexibility of proteins and their ability to link with other molecules, an area of study which opens enormous possibilities for the design of new drugs.

Scientists from the Institute for Research in Biomedicine (IRB Barcelona), the Life Sciences Programme at the Barcelona Supercomputing Center (BSC) and the National Institute for Bioinformatics (INB) have published a provisional “atlas” of the dynamic behaviour of proteins in the prestigious scientific journal, Proceedings of the National Academy of Sciences USA. Proteins determine the shape and structure of cells and drive nearly all of a cell’s vital processes.All proteins carry out their functions according to the same process – by binding with other molecules. Now, the scientists have compiled a map that shows them how proteins can move and form complexes, a valuable tool that will help them understand the basic functions of the molecules, but also what happens when they function incorrectly. Such a map opens vast possibilities for the design of new drugs.

The goal of this study is to define a map of the dynamic properties of a very representative group of proteins....

click on the link above(title) for more info..